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DTSTAMP:20260405T175549Z
UID:1705579200@ist.ac.at
DTSTART:20240118T130000
DTEND:20240118T140000
DESCRIPTION:Speaker: Andreas Sagner\nhosted by Lora Sweeney\nAbstract: The 
 molecular mechanisms that ensure the reproducible specification of neurona
 l diversity in the vertebrate nervous system are incompletely understood. 
 My recent work revealed the existence of a temporal patterning program\, c
 onsisting of cohorts of transcription factors that are expressed in neuron
 s generated at successive developmental timepoints in large regions of the
  developing nervous system. This program is superimposed on the well-known
  spatial patterning programs that subdivide the vertebrate nervous system 
 into topographical territories and direct the specification of distinct ne
 uronal classes at characteristic positions. Focussing on the developing sp
 inal cord\, I will provide evidence that this temporal program is essentia
 l and works in combination with the programs that control spatial patterni
 ng to partition neurons in the early spinal cord into distinct molecular a
 nd functional identities. This includes long-range projection neurons of t
 he anterolateral system\, which relay sensory information from the spinal 
 cord to different areas of the brain and the specification of distinct col
 umnar identities of motor neurons.
LOCATION:Moonstone Bldg / Ground floor / Seminar Room F\, ISTA
ORGANIZER:judit.gazsi@ist.ac.at
SUMMARY:Andreas Sagner: Neuronal subtype specification in the developing ne
 rvous system by a shared temporal TF sequence
URL:https://talks-calendar.ista.ac.at/events/4693
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