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DTSTAMP:20260424T143403Z
UID:6576f6d697c62769636652@ist.ac.at
DTSTART:20240108T100000
DTEND:20240108T110000
DESCRIPTION:Speaker: Jean-François Joanny\nhosted by Edouard Hannezo\nAbst
 ract: During metastasis cancer cells migrate collectively through conjonct
 ive tissues that can be considered as elastic or visco-elastic media. Expe
 riments in particular by P. Friedl and E.Sahai have shown that there exist
  several types of migration patterns for collective cell migration in thes
 e tissues showing for example "avenues" along which the cells move in the 
 same direction.  This talk presents two approaches to study the patterns
  of collective cell migration.  We first present an active hydrodynamic t
 heory of the cells' migration in an elastic medium by considering them as 
 an active polar fluid permeating through an elastic gel. We discusss the v
 arious instabilities of unifomly moving cells and compare the results to t
 he various modes of migration observed experimentally: Individual cell mot
 ion\, Multicellular streaming and collective cell migration.We also presen
 t a more microscopic model where we consider individual cells\, which remo
 del the extracellular matrix both by secreting and degrading it. A very si
 mplified model leads to non-equilibrium phase diagrams that show very unus
 ual equilibria between dilute isotropic and concentrated nematic cell phas
 es and  between two different nematic phases. 
LOCATION:Moonstone Bldg / Ground floor / Seminar Room F (I24.EG.030f)\, IST
 A
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Jean-François Joanny: Pattern formation in collective cell migrati
 on
URL:https://talks-calendar.ista.ac.at/events/4651
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