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DTSTAMP:20260424T102213Z
UID:64facab72e90d684282559@ist.ac.at
DTSTART:20231214T130000
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DESCRIPTION:Speaker: Nikolas Claussen\nhosted by Edouard Hannezo\nAbstract:
  Animal development requires large numbers of cells to choreograph their f
 orce generation in order to sculpt tissues and organs. On a coarse scale\,
  cell motion resembles laminar fluid flow\; yet in contrast to a fluid\, e
 pithelial cells adhere to each other and maintain actively generated inter
 nal tension. To resolve this apparent paradox\, we leverage the fact that 
 cellular forces equilibrate rapidly compared to the speed of development\,
  and formulate a geometrical model for the network of balanced active tens
 ions in an epithelial sheet. Within this framework\, we can investigate ho
 w cells adiabatically remodel the tension network to change tissue shape. 
 A simple winner-takes-all'' mechanical feedback loop can self-organize com
 plex cell movement\, matching experimental data on the cell and tissue sca
 le. We find that the ability to self-organize depends on initial order in 
 the cellular packing. Cell rearrangement degrades this order so that tissu
 e flow is self-limiting. Our model explains how genetic patterning\, embry
 o geometry\, and cellular packing geometry combine to determine tissue sha
 pe change.[joint work with Fridtjof Brauns & Boris Shraiman]
LOCATION:Mondi 2 / Central Building\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Nikolas Claussen: A Geometric Tension Dynamics Model of Epithelial 
 Convergent Extension
URL:https://talks-calendar.ista.ac.at/events/4641
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