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UID:64a2d6ce68dc6480181358@ist.ac.at
DTSTART:20231121T160000
DTEND:20231121T170000
DESCRIPTION:Speaker: Sandra Siegert and Jake Watson\nAbstract: Speaker: San
 dra Siegert (PI\, Siegert Group)Title: Recovery of ketamine-anesthesia dif
 fers between sexesAbstract: Brain network activity depends on an adequate 
 interplay between neurons across brain regions. Anesthetics like ketamine 
 induce a reversible state in brain oscillation and alters the excitatory a
 ction in the brain. We have recently shown that repeated ketamine-induced 
 anaesthesia causes the loss of the perineuronal nets (PNN)\, a physical ex
 tracellular barrier that surrounds interneurons\, and reestablishes juveni
 le ocular dominance plasticity in the adult mouse visual cortex (V1). Micr
 oglia are key in enabling this PNN dismantling\, since their depletion pre
 vents this effect. Still\, the microglia-neuronal signatures that gives ri
 se to the ketamine-induced plasticity is still incomplete. In solving this
  question\, we decided to look at acute effects of ketamine and discovered
  sexual differences on the neuron- and microglia-level with consequences o
 n brain oscillation network.Speaker: Jake Watson (Postdoc\, Jonas Group)Ti
 tle: Determining the microcircuits of the human brainAbstract: Our brains
  action arises from a constant flow of activity through specific cells via
  specific synapses. Therefore understanding brain functioning requires an 
 understanding of the properties and wiring of functioning microcircuits. T
 he vast majority of our knowledge of mammalian circuit function comes from
  rodent research yet how much of this actually applies to the human brain 
 cannot be known without analysis of human tissue. I will discuss how we ar
 e working to determine the microcircuit properties of the human hippocampu
 s. Using patient derived tissue in a cross species analysis we can both di
 rectly report the properties of human circuits\, but also provide a perspe
 ctive on evolutionary conserved and divergent features of circuit function
 .
LOCATION:Central Bldg / O1 / Mondi 2 (I01.O1.008)\, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Sandra Siegert and Jake Watson: NDT by Sandra Siegert and Jake Wats
 on
URL:https://talks-calendar.ista.ac.at/events/4601
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