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DTSTAMP:20260424T123707Z
UID:64a2d6ce68dbf394079832@ist.ac.at
DTSTART:20231114T160000
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DESCRIPTION:Speaker: Tomas Masson\nAbstract: Evolution of Molecular Substra
 tes for Neuronal WiringAnimals exhibit a wide array of natural behaviors\,
  yet the connection between these ethological adaptations and the underlyi
 ng evolutionary changes of the neuronal systems controlling them remains l
 argely unknown. Characterizing these adaptive processes is fundamental for
  gaining a comprehensive understanding of neuronal computations\, their fu
 nction\, and the broader landscape of evolution. In this presentation\, I 
 will provide insights into my ongoing research aimed at unraveling these a
 daptive processes\, with a focus on the well-defined and accessible Drosop
 hila's motion vision circuitry. To bridge the gap between the molecular bl
 ueprint that defines neural circuitry and the innate behaviors exhibited a
 cross species\, I'm employing a comprehensive bottom-up approach that enco
 mpasses spatial proteomics\, phylogenetic reconstructions\, and high-throu
 ghput behavioral analysis. My results show that neuron-specific surface pr
 oteomes are highly enriched in cell adhesion molecules that can exhibit bo
 th\, highly conserved and extremely divergent phylogenetic profiles\, indi
 cating species-specific adaptations. Notably\, when integrating these prot
 eomic datasets with single-cell RNA-sequencing and the fly brain connectom
 e\, we unveil synapse-specific molecular interactions that serve as the fo
 undation for circuit-level functional experiments. Currently\, I am develo
 ping tools to validate these candidate wiring interactions\, both at the a
 natomical and behavioral levels. These efforts will advance our understand
 ing of the intricate relationship between neural circuits and the adaptive
  processes that shape species behaviors.
LOCATION:Central Bldg / O1 / Mondi 2a (I01.O1.008)\, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Tomas Masson: NDT talks
URL:https://talks-calendar.ista.ac.at/events/4591
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