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DTSTART:20120325T030000
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DTSTART:20121028T020000
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BEGIN:VEVENT
DTSTAMP:20260505T161400Z
UID:5004044cdf5ff@ist.ac.at
DTSTART:20120423T163000
DTEND:20120423T173000
DESCRIPTION:Speaker: Laurence Hurst\nAbstract: There is considerable variat
 ion in the rate at which different genes evolve. Why is\nthis? Classically
  it has been considered that the density of functionally important\nsites 
 must predict rates of protein evolution.\nLikewise\, amino acid choice is 
 usually assumed to reflect optimal protein function\nand codon choice is r
 andom. Here I briefly review evidence suggesting that this\nview is too si
 mplistic. In particular I concentrate on how selection acting during the\n
 protein’s production history can also affect gene evolutionary rates as w
 ell as amino\nacid and codon choice.\nExploring the role of selection at t
 he DNA and RNA level\, I specifically address how\nthe need 1) to specify 
 exonic splice enhancer motifs in pre-mRNA and 2) to ensure\nnucleosome pos
 itioning on DNA\, impacts amino acid choice\, codon choice and rates\nof e
 volution at both synonymous and non-synonymous sites.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:ihetzenauer@ist.ac.at
SUMMARY:Laurence Hurst: Institute Colloquium: Why there is more to gene evo
 lution than protein function: spli
URL:https://talks-calendar.ista.ac.at/events/454
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