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DTSTAMP:20260424T074513Z
UID:1701183600@ist.ac.at
DTSTART:20231128T160000
DTEND:20231128T170000
DESCRIPTION:Speaker: Radu Aricescu\nhosted by Mario De Bono\nAbstract: Type
 -A gamma-aminobutyric receptors (GABAARs) are the principal mediators of r
 apid inhibitory synaptic transmission in the human brain. They form a larg
 e family of pentameric ligand-gated chloride channels\, with a rich pharma
 cology and involved in virtually all aspects of brain function. Many GABAA
 R modulators\, including benzodiazepines and general anaesthetics\, are am
 ong the most successful drugs in clinical use (and often substances of abu
 se). I will discuss our journey towards the structural characterisation 
 of human GABAARs and their vast molecular diversity. This work led to insi
 ghts into the mechanisms of GABA-ergic signalling\, a rational basis for t
 he development of novel GABAAR modulators\, and multiple unexpected findin
 gs that will keep us and others busy for the foreseeable future.
LOCATION:Mondi 2\, ISTA
ORGANIZER: Evan.Casella@ist.ac.at
SUMMARY:Radu Aricescu: The wild wide world of human GABAA receptors
URL:https://talks-calendar.ista.ac.at/events/4524
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