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TZID:Europe/Vienna
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DTSTART:20120325T030000
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DTSTART:20121028T020000
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BEGIN:VEVENT
DTSTAMP:20260505T221026Z
UID:5004044cea687@ist.ac.at
DTSTART:20120326T163000
DTEND:20120326T173000
DESCRIPTION:Speaker: Thomas Silhavy\nAbstract: The outer membrane (OM) of G
 ram-negative bacteria functions as a protective barrier. It\nis unusual be
 cause the OM bilayer is asymmetric\; the inner leaflet is composed of\npho
 spholipids\, but the outer leaflet is made of lipopolysaccharide (LPS). Tw
 o kinds of\nproteins are found in the OM. Lipoproteins are inserted into t
 he inner leaflet of the OM by\nposttranslationally attached lipid moieties
 . Integral OM proteins are b-barrel proteins\n(OMPs). We have used genetic
 \, bioinformatic and biochemical strategies to identify and\ncharacterize 
 the cellular components required for LPS and OMP biogenesis. After\ndescri
 bing what is known about these essential cellular processes\, I will focus
  on the\ngenetic approaches we are taking to probe the mechanism by which 
 ?-barrel assembly\nmachine folds and inserts OMPs into the OM. This machin
 e is composed of a large ?-barrel\nprotein\, BamA\, and four lipoproteins\
 , Bam BCDE. My talk will focus on the role of BamE\nand how the two essent
 ial proteins\, BamA and BamD communicate with each other.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:ihetzenauer@ist.ac.at
SUMMARY:Thomas Silhavy: Institute Colloquium: Outer membrane biogenesis in 
 Gram-negative bacteria
URL:https://talks-calendar.ista.ac.at/events/452
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