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DTSTART:20120325T030000
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DTSTAMP:20260505T221026Z
UID:5004044cece8b@ist.ac.at
DTSTART:20120319T163000
DTEND:20120319T173000
DESCRIPTION:Speaker: Thomas Lecuit\nAbstract: Tissues exhibit a remarkable 
 dual property of robustness and plasticity.\nThis relies on unique mechani
 cal properties of the cell cortex and on adhesive interactions\nbetween ce
 lls. Our group seeks to understand the fundamental molecular mechanisms\nr
 esponsible for this property. This is essential to understand morphogenesi
 s of developing\nembryos and organs\, and is severely affected in a number
  of diseases\, in particular cancer\nprogression.\nTo that end we develop 
 a range of approaches\, from the genetic and pharmacological\nperturbation
 s of molecular components\, the quantitative imaging of proteins using a\n
 variety of photonic methods\, probing of the physical properties of cells 
 within intact\ntissues\, and predictive computational modelling of morphog
 enesis at different scales\n(molecular to tissue scales).\nI will present 
 our current research characterizing how adhesion and cortical tension\nreg
 ulate the dynamic remodelling of cell contacts in the primary epithelium o
 f Drosophila\nembryos. I will first focus on the regulation of tensile act
 ivity driving cell shape changes. I\nwill also address how E-cadherin-acti
 n interactions control force transmission at cell\ninterfaces.\nTissue gro
 wth imposes challenges to tissue cohesion. In a second part I will report 
 on our\nstudies of the interplay between tissue growth and tissue mechanic
 s during\nmorphogenesis
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:ihetzenauer@ist.ac.at
SUMMARY:Thomas Lecuit: Institute Colloquium: Biomechanics of tissue morphog
 enesis: from local to global scal
URL:https://talks-calendar.ista.ac.at/events/451
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