BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20230326T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20231029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260424T040706Z
UID:64a2da343c88f627174465@ist.ac.at
DTSTART:20231017T160000
DTEND:20231017T170000
DESCRIPTION:Speaker: Nils Brose\nhosted by Peter Jonas\nAbstract: The proce
 ss of synaptic vesicle priming is an essential determinant of the function
 \, strength\, and plasticity of nerve cell synapses\, because it maintains
  a pool of readily releasable vesicles at any given time and determines th
 e time course of synaptic fatigue and recovery. The corresponding forms of
  synaptic short-term plasticity determine multiple complex brain functions
 \, from sensory adaptation to working memory. Munc13s execute synaptic ves
 icle priming by regulating the assembly of fusogenic SNARE complexes. They
  are themselves regulated by three major pathways\, involving (i) calcium-
 calmodulin signaling via dedicated amphipathic calcium-calmodulin binding 
 sites\, (ii) diacylglycerol signaling via C1 domains\, and (iii) calcium-p
 hospholipid signaling via C2 domains. We studied the functional relevance 
 of these regulatory pathways in various synapse types and found that calci
 um-dependent Munc13-regulating pathways are major determinants of synaptic
  short-term plasticity\, synapse endurance\, and synaptic fidelity. I will
  discuss these data in the context (i) of the combined role of signaling p
 athways that target presynaptic function\, (ii) of the role of Munc13 prim
 ing proteins in determining the unique features of regulated exocytosis at
  nerve cells synapses\, and (iii) of the role of these processes in physio
 logical and pathophysiological circuit function.
LOCATION:Office Bldg West / Ground floor / Heinzel Seminar Room (I21.EG.101
 )\, ISTA
ORGANIZER:Eleftheria.KralliBeller@ist.ac.at
SUMMARY:Nils Brose: Dynamic regulation of presynaptic function and plastici
 ty in health and disease
URL:https://talks-calendar.ista.ac.at/events/4496
END:VEVENT
END:VCALENDAR