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DTSTAMP:20260406T024402Z
UID:64a2d9f20d03a142334168@ist.ac.at
DTSTART:20231003T160000
DTEND:20231003T170000
DESCRIPTION:Speaker: Scott Soderling\nhosted by Tomas Masson\nAbstract: Syn
 aptic plasticity and genetic risk factors are pivotal in decoding the myst
 eries of neurological disorders. In this talk\, I'll unveil novel proteomi
 cs techniques that shed light on the intricate molecular dance at synaptic
  junctions in vivo and the unique interactomes linked to neurodevelopmenta
 l disorders. First\, Ill discuss recent presynaptic proteomics\, where we 
 have uncovered a dynamic signaling pathway that orchestrates synaptic vesi
 cle replenishment across both excitatory and inhibitory synapses. This dis
 covery has led to a new understanding of mechanisms for short-term presyna
 ptic plasticity\, that appears crucial for working memory. Next\, Ill pivo
 t to the enigma of autism spectrum disorder (ASD). Here\, we identify high
 -confidence autism risk interactomes in the mouse brain\, which strikingly
  mirror dysregulations observed in human autistic brains. This revelation 
 hints at novel avenues to prioritize genetic risk and emphasizes shared ce
 llular functions that might be at the heart of ASD. Together these stories
  will detail new approaches for neural proteomics and novel mechansims tha
 t drive the balance of synaptic plasticity and genetic underpinnings in ne
 urological conditions.
LOCATION:Office Bldg West / Ground floor / Heinzel Seminar Room (I21.EG.101
 )\, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Scott Soderling: Won’t You Be My Neighbor? Proximity Proteomics t
 o Uncover Neural Mechanisms of Adaptive and Maladaptive Synaptic Mechanism
 s
URL:https://talks-calendar.ista.ac.at/events/4473
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