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UID:64a2d75d25c59361558368@ist.ac.at
DTSTART:20230919T160000
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DESCRIPTION:Speaker: Rune W. Berg\nhosted by Tim Vogels\nAbstract: Most of 
 the investigations on spinal rhythm generation are based on motor nerve re
 cordings and single neuron recordings. Since flexor/extensor muscles alter
 nate during movements\, it is often assumed that the generation is accompl
 ished by neuronal modules that alternate in opposition\, which single neur
 on recordings seem to support. However\, here we argue that when many neur
 ons are monitored simultaneously a different picture emerges. We recorded 
 hundreds of neurons from the lumbar spinal cord of turtles and rats during
  rhythmic movement (walking and scratching) and found that\, rather than a
 lternating\, the neuronal population is performing a "rotation"\, i.e. cyc
 ling continuously through all phases. Rotational dynamics are observed acr
 oss trials as well as behaviors. Since such rotation is difficult to expla
 in with existing models of alternating neuronal groups\, we propose a new 
 theory that accounts for the rotational dynamics. Using a simplified netwo
 rk model\, we show that in spinal networks with recurrent excitatory and i
 nhibitory connectivity\, there is no need for pacemaker activity\, CPG-lay
 ers or modular structures. Tonic input to the network controls the rhythm 
 and pattern depending on the task. The model also reproduces other experim
 ental observations and provides a mechanism for multifunctionality. To fur
 ther investigate spinal circuits\, we investigate the modulatory effects o
 f the brain (Pedunculopontine nucleus) on the spinal population activity d
 uring the volitional locomotion of the rat.Short bio:Rune got his master d
 egree in physics and biophysics at University of Copenhagen\, after which 
 he went to graduate school to work with Professor David Kleinfeld at Unive
 rsity of California\, San Diego\, where he work on the motor control of th
 e whiskers of rodents. In 2003-4\, after 6 years with David at UCSD\, he d
 id a short post doc at the Veterans hospital in Taipei in Taiwan\, working
  with spinal cord injury with Professor Henrich Cheng. Then in 2004 he wen
 t back to University of Copenhagen to work with Hounsgaard doing a post do
 c on single intracellular recordings from spinal neurons in turtles. In 20
 08 he started forming his own lab and in 2013 he became tenured associate 
 professor at the Department of Neuroscience. His research focus is a netwo
 rk approach to understand the nervous system\, especially the motor system
 .https://scholar.google.com/citations?user=x1QHxIUAAAAJ&hl=en 
LOCATION:Office Bldg West / Ground floor / Heinzel Seminar Room (I21.EG.101
 )\, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Rune W. Berg: Rotational neural dynamics in the spinal cord and a n
 ew theory of movement
URL:https://talks-calendar.ista.ac.at/events/4390
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