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DTSTAMP:20260424T040538Z
UID:1693227600@ist.ac.at
DTSTART:20230828T150000
DTEND:20230828T160000
DESCRIPTION:Speaker: Amit Zeisel\nhosted by Lora Sweeney\nAbstract: Teleost
  fish form the largest group of vertebrates\, making them critically impor
 tant for the study on the mechanisms of brain evolution. In fact\, teleost
 s show a tremendous variety of adaptive behaviors similar to birds and mam
 mals\, however\, the neural basis mediating these behaviors remains elusiv
 e. We performed a systematic comparative survey of the goldfish telencepha
 lon\; the seat of plastic behavior\, learning and memory in vertebrates. W
 e delineated and mapped goldfish telencephalon cell types using single-cel
 l RNA-seq and spatial transcriptomics\, resulting in de novo molecular n
 euroanatomy parcellation. Glial cells were highly conserved across 450 mil
 lion years of evolution separating mouse and goldfish\, while neurons show
 ed diversity and modularity in gene expression. Specifically\, somatostati
 n (SST) interneurons\, famously interspersed in the mammalian isocortex fo
 r local inhibitory input\, were curiously aggregated in a single goldfish 
 telencephalon nucleus\, but molecularly conserved. Cerebral nuclei includi
 ng the striatum\, a hub for motivated behavior in amniotes\, had molecular
 ly and spatially conserved goldfish homologues. We further suggest differe
 nt elements of a hippocampal formation across the goldfish pallium. Toget
 her\, our atlas provides new insights to organization and evolution of ver
 tebrate forebrains and may serve as a resource for the functional study un
 derlying cognition in teleost fish.
LOCATION:Central Building Mondi 2\, ISTA
ORGANIZER:judit.gazsi@ist.ac.at
SUMMARY:Amit Zeisel: Evolution of Telencephalon Spatial Structures and Cell
  types
URL:https://talks-calendar.ista.ac.at/events/4372
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