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DTSTAMP:20260424T041236Z
UID:1696924800@ist.ac.at
DTSTART:20231010T100000
DTEND:20231010T110000
DESCRIPTION:Speaker: Georg E. Winter\nhosted by Gaia Novarino\nAbstract: Ch
 emical modulation of protein function enables us to understand biological 
 mechanisms and represents the foundation for most medicines. For decades\,
  efforts in small-molecule discovery focused on ligands that block the bio
 chemical activity of their target proteins. However only around 20% of all
  human proteins feature biochemically active ligand binding sites that can
  be addressed with small-molecule inhibitors. The resulting shortage in ch
 emical tools hampered our ability to functionally interrogate many biologi
 cal processes and precipitated in a lack of treatment options for a pletho
 ra of diseases.To close this gap and to chemically access the entirety of 
 the human proteome\, our group is thus exploring the new paradigm of “ch
 emical neomorphs”. Chemical neomorphs are small molecules that can repro
 gram biological circuits beyond evolutionary constraints by endowing targe
 t proteins with new functions. Mechanistically\, they function by installi
 ng novel protein-protein interactions\, don’t require additional genetic
  manipulations and thus also harbor tremendous translational and therapeut
 ic potential.In my seminar\, I will discuss our research on chemical neomo
 rphs that can reprogram E3 ubiquitin ligases to induce the degradation of 
 a variety of disease-causing target proteins that are traditionally consid
 ered to be “undruggable”. In particular\, I will share how we connect 
 functional genomics and other multi-omics approaches with synthetic chemis
 try to identify and mechanistically characterize such small-molecule degra
 ders. Moreover\, I will discuss how the concept of chemical neomorphs can 
 be expanded beyond the scope of chemically induced targeted protein degrad
 ation\, for instance by developing pharmacologic strategies to rewire tran
 scriptional circuits.
LOCATION:Mondi 2\, Central Building\, ISTA
ORGANIZER:omerhalil.unal@ist.ac.at
SUMMARY:Georg E. Winter: Chemical neomorphs: Reprogramming biological circu
 its with small molecules
URL:https://talks-calendar.ista.ac.at/events/4369
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