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DTSTAMP:20260406T024020Z
UID:1694692800@ist.ac.at
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DESCRIPTION:Speaker: Alexandre Bisson\nhosted by Martin Loose\nAbstract: Ce
 lls sense and respond to their physical surroundings using organized molec
 ular machinery that is tightly regulated in space and time. The Bisson L
 ab is interested in the biophysical and spatio-temporal control of unusual
  cell shape transitions\, how these traits evolved and the signals respons
 ible for such shapeshift events. We combine state-of-the-art microscopy ra
 nging from single-cell and single-molecule tracking\, microfabrication\, g
 enetics\, and biochemistry to study the molecular mechanisms of cell shape
  formation across over 100 different archaeal species. Here\, I will discu
 ss our recent finding around one of the main hypotheses: that instead of r
 eading out mainly their chemical and metabolic environment\, archaeal cell
 s evolved to sense physical cues in order to build different cell shapes a
 nd mediate social behavior within the same and across different species. T
 heir accurate mechanosensing brings significant implications for cell cycl
 e regulation\, cytoskeleton dynamics\, and the emergence of a set of compl
 ex molecular factors present in eukaryotes\, including animal tissue. We o
 bserved that cells respond to shear stress (shape-shifting transitions bet
 ween polygons and rods) and confinement (transitioning from single- to tis
 sue-like multicellular lifestyle). We speculate on possible evolutionary f
 actors that enable archaeal cells to conserve such "squishy" properties an
 d their connection to the microbiome's social interactions.
LOCATION:Sunstone Building - Big Seminar Room B \, ISTA
ORGANIZER:
SUMMARY:Alexandre Bisson: The perks of being squishy:  Archaea as a skillfu
 l mechanoresponsive machine
URL:https://talks-calendar.ista.ac.at/events/4356
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