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DTSTART:20110327T030000
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DTSTAMP:20260513T182550Z
UID:5004044d47498@ist.ac.at
DTSTART:20110912T164500
DTEND:20110912T174500
DESCRIPTION:Speaker: John Lisman\nAbstract: The hippocampal system is neede
 d for episodic memory\, a form of memory in which event\nsequences play a 
 critical role. There is now substantial evidence that information is store
 d in the\nhippocampus by long-term potentiation (LTP)\, a process by which
  repetitive high frequency firing\nproduces a long-lasting increase in the
  strength of synapses. The entorhinal cortex is the brain\nregion that pro
 vides input to the hippocampus\, but it has been unclear whether this stru
 cture can\nproduce the repetitive firing about recent events required to p
 roduce LTP. We have studied the\nfiring pattern of grid cells in the entor
 hinal cortex and found that they do exhibit such firing\npatterns\; we ter
 m this the retrospective mode. This mode alternates on a second by second 
 basis\,\nwith a different “predictive” mode in which the system represen
 ts upcoming positions. This\nalternation may be a solution to the general 
 problem of how to organize separate storage and\nrecall processes and equi
 valent to the read/wrote modes of computer memory. In the second part\nof 
 my talk I will talk about progress in understanding the molecular processe
 s by which memory is\nstored at synapses. The abundant brain protein kinas
 e\, CaMKII\, is activated during LTP\, and can\nthen bind at the synapse t
 o the NMDA receptor. We have shown that dissociating this complex\ncan era
 se previously induced LTP. Thus the CaMKII/NMDAR complex is now a leading 
 candidate as\nthe molecular basis of memory
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:ihetzenauer@ist.ac.at
SUMMARY:John Lisman: Network and Molecular Mechanisms of Memory
URL:https://talks-calendar.ista.ac.at/events/435
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