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DTSTAMP:20260424T041231Z
UID:64a2e2b97acd5516104980@ist.ac.at
DTSTART:20230714T150000
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DESCRIPTION:Speaker: Tim Viney\nhosted by Sandra Siegert\nAbstract: Deficit
 s in spatial navigation and orientation are associated with early cognitiv
 e decline prior to Alzheimers disease. The apparent spread of pathological
  misfolded forms of the Tau protein (pTau) across different areas of the c
 erebral cortex correlates with cognitive decline\, and this is thought to 
 be initially driven by the spread of pTau from the entorhinal cortex to th
 e hippocampus. The anterior thalamus acts as a relay for sensorimotor mess
 ages concerning orientation and space to reach the cortex. We observed in 
 post-mortem human thalamus that the anterodorsal nucleus is unusually vuln
 erable to pTau at all stages of disease progression\, even in cognitively 
 unimpaired cases. Using double-labelling pre-embedding immunohistochemistr
 y and electron microscopy\, we discovered that large glutamatergic presyna
 ptic terminals from the mammillary body accumulated pTau\, but corticothal
 amic terminals did not\, even at the stage before Alzheimers disease. Furt
 hermore\, we detected pTau+ filaments at both presynaptic and postsynaptic
  sites\, suggesting a previously unrecognized subcortical route for the tr
 anssynaptic spread of Tau in the human brain. The anterodorsal nucleus con
 tains a high density of head direction (HD) cells\, but the neurochemical 
 identity and synaptic targets of individual thalamic HD cells are unknown.
  We use extracellular recordings and juxtacellular labelling in awake mice
  to define single HD cells in order to make predictions about the conseque
 nces of their dysfunction in humans. Spatial orientation deficits\, relati
 ng to activity in the anterodorsal nucleus\, could be a good predictor of 
 future cognitive impairment leading to Alzheimers disease. 
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room A + B (I23.EG.102)
 \, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Tim Viney: Glutamatergic drivers for spatial orientation and Tau pr
 opagation
URL:https://talks-calendar.ista.ac.at/events/4294
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