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DTSTART:20230326T030000
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DTSTART:20231029T020000
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BEGIN:VEVENT
DTSTAMP:20260424T143123Z
UID:1687523400@ist.ac.at
DTSTART:20230623T143000
DTEND:20230623T153000
DESCRIPTION:Speaker: Hitoshi Okamoto\nhosted by Ryuichi Shigemoto\nAbstract
 : The habenula is located dorsal to the thalamus in the diencephalon and i
 s divided into medial and lateral subregions in mammals. With respect to t
 he lateral part\, it has been shown that it encodes negative reward predic
 tion errors and is deeply involved in value-based decision-making such as 
 active avoidance behaviors\, but the neural pathway from the medial part t
 o the interpeduncular nucleus has long been unknown\, even though it is on
 e of the most evolutionarily conserved pathways. Using adult zebrafish as 
 material\, we found that this homologous pathway is composed of two parall
 el pathways that antagonize each other to control emotional and decision-m
 aking behaviors\, including social fighting behavior\, with one pathway be
 ing used to predict interoceptive perception to realize a preferred postur
 e for attacking an opponent or obtaining a reward and the other to attend 
 to exteroceptive perception to evaluate whether the external world is safe
  or dangerous. In this talk\, I will talk about our strategy to gain a com
 plete picture of the neural circuit mechanisms of behavioral control by th
 ese pathways. I will also mention our efforts to elucidate the evolutionar
 y conservation of these pathways in the control of emotional and decision-
 making behavior by using mice and comparing the results with those obtaine
 d in zebrafish.
LOCATION:CB\, Mondi 3\, ISTA
ORGANIZER:omerhalil.unal@ist.ac.at
SUMMARY:Hitoshi Okamoto: The roles of the habenula-interpeduncular pathways
  in the integration of interoception and exteroception for decision making
URL:https://talks-calendar.ista.ac.at/events/4280
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