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DTSTAMP:20260426T074530Z
UID:63199ef5bd9aa592478413@ist.ac.at
DTSTART:20230622T110000
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DESCRIPTION:Speaker: Lea-Laetitia Pontani\nhosted by Jérémie Palacci\nAbs
 tract: We use biomimetic emulsions to understand the physical basis of col
 lective remodeling in biological tissues. In particular\, we focus on the 
 interplay between adhesion and extrinsic mechanical forces to control the 
 emergence of tissue architecture during morphogenesis. We design our emuls
 ions to reproduce the passive mechanical and adhesive properties of cells 
 in biological tissues and we study their elasto-plastic response to an app
 lied mechanical perturbation. In simple microfluidic constrictions we find
  that adhesion alone can polarize the droplets in the direction of the flo
 w. This result indicates that adhesion alone could in principle induce cel
 l polarization in elongating tissues\, which could in turn trigger signali
 ng inside the cells. We are now exploring how adhesion hierarchies inside 
 such systems can lead to self-organization of the biomimetic tissue throug
 h repeated mechanical stimulations.Conversely\, in static packings we unco
 ver a threshold proportion of adhesive contacts above which adhesion perco
 lation in the contact network sets the deformation of all droplets in the 
 packing\, independently of their local adhesive properties. In biological 
 tissues\, this indicates that tuning the adhesion properties in a limited 
 number of cells at a given packing fraction should be sufficient to modify
  globally the mechanical properties of the tissue.Finally\, in parallel to
  these in vitro approaches\, we use oil droplets as force sensors in vivo\
 , in developing zebrafish embryos. In particular\, the injection of biocom
 patible oil droplets in their olfactory placode allowed us to measure the 
 presence of anteroposterior compressive forces that can contribute to axon
  elongation in olfactory neurons. We are currently developing biocompatibl
 e self-functionalizing droplets in order to obtain the full force map in t
 he placode and in surrounding tissues during development.
LOCATION:Office Bldg West / Ground floor / Heinzel Seminar Room (I21.EG.101
 )\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Lea-Laetitia Pontani: Biomimetic emulsions as a tool to investigate
  tissue mechanics in vitro and in vivo
URL:https://talks-calendar.ista.ac.at/events/4272
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