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DTSTAMP:20260424T063041Z
UID:6267c1da514d7743260316@ist.ac.at
DTSTART:20230613T160000
DTEND:20230613T170000
DESCRIPTION:Speaker: Vered Kellner\nhosted by Peter Jonas\nAbstract: Sponta
 neous neuronal activity emerges from developing sensory organs before they
  can respond to the external world. The mechanisms through which this high
 ly stereotyped neuronal burst firing induces maturation of sensory systems
  remains poorly understood. Astrocytes\, one of the major glial cell types
  in the brain\, promote the formation and function of neuronal synapses\; 
 however\, it has not been possible to monitor the activity of these distin
 ct cell types in living animals during this crucial period of circuit refi
 nement. Using selective genetic manipulations and in vivo imaging in awake
  mouse pups\, we demonstrate that astrocytes and neurons exhibit highly co
 ordinated spontaneous activity before the onset of hearing within sound pr
 ocessing regions of the auditory midbrain and cortex. Astrocyte calcium ev
 ents occurred in response to the most intense neuronal events and were med
 iated by synergistic activation of two types of metabotropic glutamate rec
 eptors on astrocytes. Coordinated activity between neurons and astrocytes 
 was restricted to a narrow developmental time window\, disappearing after 
 hearing onset. Transcriptional profiling of the developing auditory midbra
 in in mice with genetic silencing of astrocyte calcium signaling revealed 
 that both astrocyte and neuron maturation relied on astrocyte activity dur
 ing this period. These results show for the first time the involvement of 
 astrocyte calcium signaling in the maturation of neuronal circuits within 
 the intact brain\, advancing our understanding of how neuronal burst firin
 g is used to promote brain development. Identifying astrocytes as mediator
 s of this process provides potential new therapeutic targets for treating 
 neurodevelopmental disabilities\, such as autism spectrum disorder.
LOCATION:Central Bldg / O1 / Mondi 2 (I01.O1.008)\, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Vered Kellner: The role of astrocyte calcium signaling in developin
 g sensory domains
URL:https://talks-calendar.ista.ac.at/events/4267
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