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DTSTAMP:20260424T143503Z
UID:6267c1da514cf973028104@ist.ac.at
DTSTART:20230606T160000
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DESCRIPTION:Speaker: Nathalie Agudelo Duenas\nAbstract: Biological systems 
 are intrinsically heterogeneous\, from the level of molecular arrangements
  and interactions to whole tissue organization. To understand the complexi
 ty of these systems\, it is fundamental to study them in their native cont
 ext\, which requires assessing their intricate structure and function in a
  spatially informed manner. Over the last decade\, there has been a rapid 
 advancement in the field of spatial omics\, especially at the transcript l
 evel measuring gene expression\, which has been instrumental in understand
 ing how mRNA distribution and abundance define cell identity and function.
  This project aims to develop a highly multiplexed and modular methodology
  for integrated structural and multi-molecular characterization\, as a mea
 ns to visualize the spatial arrangement of the transcriptome with subcellu
 lar to tissue context. Given the importance of the compartmentalized organ
 ization of mRNAs (local transcriptome) in neurons\, I designed a 242-gene 
 MERFISH codebook to target neuron-specific transcripts and applied it in m
 ouse cultured neurons and brain tissue. Currently\, I am combining transcr
 iptional and morphological information with the aim of correlating structu
 re and its molecular constituents. This will ultimately allow the characte
 rization of the local transcriptome\, to better understand how neurons res
 pond to their functional demands and regulate protein homeostasis in both 
 health and disease.
LOCATION:Central Bldg / O1 / Mondi 2 (I01.O1.008)\, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Nathalie Agudelo Duenas: Visualizing the transcriptional landscape 
 with tissue context
URL:https://talks-calendar.ista.ac.at/events/4266
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