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DTSTART:20240331T030000
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BEGIN:VEVENT
DTSTAMP:20260405T161855Z
UID:1718616600@ist.ac.at
DTSTART:20240617T113000
DTEND:20240617T123000
DESCRIPTION:Speaker: Caetano Reis e Sousa\nhosted by Michael Sixt\nAbstract
 : Innate and adaptive immunity work concertedly in vertebrates to restore 
 homeostasis following pathogen invasion or other insults. Like all homeost
 atic circuits\, immunity relies on an integrated system of sensors\, trans
 ducers and effectors that can be analysed in cellular or molecular terms. 
 At the cellular level\, T and B lymphocytes act as an effector arm of immu
 nity that is mobilised in response to signals transduced by innate immune 
 cells that detect a given insult. These innate cells are spread around the
  body and include dendritic cells (DCs)\, the chief immune sensors of path
 ogen invasion and tumour growth. At the molecular level\, DCs possess rece
 ptors that directly sense pathogen presence and tissue damage and that sig
 nal to control antigen presentation and/or to regulate a plethora of genes
  encoding effector proteins that regulate immunity. The lecture will focus
  on understanding how DCs integrate environmental signals to drive immunit
 y to cancer\, with applications in immunotherapy. References:Giampazolias
 \, E. et al. Vitamin D regulates microbiome-dependent cancer immunity. Sci
 ence 384\, 428–437 (2024).Minutti\, C. M. et al. Distinct ontogenetic li
 neages dictate cDC2 heterogeneity. Nat. Immunol. 1–14 (2024) doi:10.1038
 /s41590-024-01745-9.Henry\, C. M.\, Castellanos\, C. A. & Reis e Sousa\, C
 . DNGR-1-mediated cross-presentation of dead cell-associated antigens. Sem
 in Immunol 66\, 101726 (2023).Cabeza-Cabrerizo\, M.\, Cardoso\, A.\, Minut
 ti\, C. M.\, Pereira da Costa\, M. & Reis e Sousa\, C. Dendritic Cells
  Revisited. Annu Rev Immunol 39\, 131–166 (2021).Cabeza-Cabrerizo\, M. e
 t al. Recruitment of dendritic cell progenitors to foci of influenza A vir
 us infection sustains immunity. Sci Immunol 6\, eabi9331 (2021).Giampazoli
 as\, E. et al. Secreted gelsolin inhibits DNGR-1-dependent cross-presentat
 ion and cancer immunity. Cell 184\, 4016-4031.e22 (2021).Canton\, J. et al
 . The receptor DNGR-1 signals for phagosomal rupture to promote cross-pres
 entation of dead-cell-associated antigens. Nature Immunology 22\, 140–15
 3 (2021).
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:maria.arias.sutil@ista.ac.at
SUMMARY:Caetano Reis e Sousa: Necrophagy\, coprophagy\, DaNGeRous indigesti
 on and immunity to cancer 
URL:https://talks-calendar.ista.ac.at/events/4254
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