BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20240331T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20231029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260424T141040Z
UID:1705314600@ist.ac.at
DTSTART:20240115T113000
DTEND:20240115T123000
DESCRIPTION:Speaker: Edmund Kunji\nhosted by Paul Schanda\nAbstract: Life r
 equires a constant supply of energy in the form of the cellular fuel adeno
 sine triphosphate (ATP). In fact\, we need our own body weight in ATP ever
 y day to drive our cellular processes. However\, we only have a small amou
 nt of ATP in our body at any time and thus it needs to be synthesised cont
 inuously from its constituent components\, the spent fuel adenosine diphos
 phate (ADP) and phosphate.Mitochondria are the primary site for ATP synthe
 sis\, which uses chemical energy in the form of food molecules. In short\,
  food molecules are broken down and the electrons from the bonds run down 
 the complexes of the respiratory chain to oxygen to form water. These comp
 lexes pump protons out of the mitochondrion\, which charges up\, generatin
 g a proton motive force\, which in turn is used by ATP synthase to remake 
 ATP from ADP and phosphate. However\, for this process to work ADP needs t
 o be imported into the mitochondrion and ATP needs to be exported by a tra
 nsport protein\, called the mitochondrial ADP/ATP carrier or adenine nucle
 otide translocase. In this way\, mitochondria in our tissues are nearly pe
 rfectly coupled\, meaning that virtually no energy is lost between the bre
 akdown of food molecules and the synthesis and transport of ATP.However\, 
 the mitochondria of brown adipose tissue are deliberately uncoupled\, mean
 ing that the energy conversion steps in mitochondria lead to the productio
 n of heat rather than the synthesis of ATP. The responsible protein is cal
 led the uncoupling protein\, which facilitates the import of protons witho
 ut generating work\, causing the tissue to heat up instead. UCP1 is inhibi
 ted by purine nucleotides\, such as ATP\, and is activated by fatty acids\
 , which are breakdown products of the fat reserves. The uncoupling process
  is important for the survival of mammals\, when they are born and when th
 ey are exposed to extended periods of low temperatures\, by heating up the
  vital organs.In this talk\, we will present our current understanding of 
 the molecular mechanism of the mitochondrial ADP/ATP carrier and the uncou
 pling protein\, which belong to the same protein family and are essential 
 for the survival of all mammals.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Edmund Kunji: To couple or to uncouple - transport steps in mitocho
 ndria that support mammalian life
URL:https://talks-calendar.ista.ac.at/events/4239
END:VEVENT
END:VCALENDAR