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DTSTAMP:20260428T144327Z
UID:58ec722e4d5d7981392695@ist.ac.at
DTSTART:20170515T110000
DTEND:20170515T120000
DESCRIPTION:Speaker: Can Tepeköylü\nhosted by Björn Hof\nAbstract: Calci
 fic aortic valve disease (CAVD) is the most prevalent heart valve disease 
 in western countries. In this disease\, valvular interstitial cells (VICs)
  undergo a phenotype switch towards osteoblasts starting to produce bone t
 issue in the heart. This leads to heart failure and patient death. The onl
 y current treatment option is surgical valve replacement including all ris
 ks of heart surgery. \nHeart valves are responsible for the unidirectional
  flow of blood during the cardiac cycle. The semilunar valves prevent the 
 blood stream from retrograde flow into the ventricles during diastole\, wh
 ereas the atrioventricular valves secure regurgitation from the ventricles
  into the atria. The pathology starts at the non-coronary sinus\, the valv
 e leaflet which is subjected to the highest oscillatory blood flow. In add
 ition\, patients with valve malformations resulting in increased turbulent
  blood flow show early development of calcific aortic valve disease. Lamin
 ar blood flow causes the endothelial cells to continuously produce nitric 
 oxide (NO)\, which is believed to keep the VICs in a quiescent state. Howe
 ver\, when turbulent flow occurs\, endothelial cells start producing pro-i
 nflammatory cytokines instead of NO leading to subsequent bone formation a
 nd cell death.\nThe field of mechanotransduction is working on identifying
  the pathways of how the mechanical stimulus is translated into a biologic
 al response. Although biological mechanisms behind the pathology are poorl
 y understood\, turbulent blood flow and mechanical strain clearly play a m
 ajor role in the pathogenesis of the disease and provide a main risk facto
 r for the development of CAVD. It remains unknown which patients finally d
 evelop CAVD and which do not. Identification of specific flow patterns and
  receptors sensing the mechanical strain would be of great clinical signif
 icance\, as they could develop a novel target for the pharmacological inhi
 bition of the development of the disease.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Can Tepeköylü: The impact of turbulent blood flow on aortic valve
  calcification
URL:https://talks-calendar.ista.ac.at/events/419
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