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DTSTAMP:20260424T101952Z
UID:63bd47397c17d488198078@ist.ac.at
DTSTART:20230525T110000
DTEND:20230525T120000
DESCRIPTION:Speaker: Elisa Floris\nhosted by Ivan Palaia (Saric group)\nAbs
 tract: Molecular sorting is a fundamental process that allows eukaryotic c
 ells to selectively concentrate specific chemical factors in appropriate c
 ell membrane subregions\, thus endowing them with different chemical ident
 ities and functional properties. A phenomenological theory of this molecul
 ar distillation process has recently been proposed [M. Zamparo\, D. Valdem
 bri\, G. Serini\, I. V. Kolokolov\, V. V. Lebedev\, L. DallAsta\, and A. G
 amba\, Phys. Rev. Lett. 126\, 088101 (2021)]\, based on the idea that mole
 cular sorting emerges from the combination of: a) phase-separation-driven 
 formation of sorting domains\, and b) domain-induced membrane bending\, le
 ading to the production of submicrometric lipid vesicles enriched in the s
 orted molecules. In this framework\, a natural parameter controlling the e
 fficiency of molecular sorting is the critical size of phase-separated dom
 ains. In the experiments\, sorting domains appear to fall into two classes
 : unproductive domains\, characterized by short lifetimes and low probabil
 ity of extraction\, and productive domains\, that evolve into vesicles tha
 t ultimately detach from the membrane system. It is tempting to link these
  two classes to the different fates predicted by classical phase separatio
 n theory for subcritical and supercritical phase-separated domains. I will
  discuss the implications of this picture in the framework of the previous
 ly introduced phenomenological theory of molecular sorting. To help in the
  analysis of experimental data\, an operational definition of the critical
  size of sorting domains is proposed. Comparison with experimental results
  shows that the statistical properties of productive/unproductive domains 
 inferred from experimental data are in agreement with those predicted from
  numerical simulations of a lattice-gas realization of the model\, compati
 bly with the hypothesis that molecular sorting is driven by a phase separa
 tion process. Molecular sorting is further investigated on top of a fluctu
 ating\, topologically-varying membrane\, simulated as a one-dimensional la
 ttice which is allowed to undergo the topological transformations correspo
 nding to fusion and detachment of molecule-loaded vesicles. In this framew
 ork\, the interplay between molecules and membrane bending is explicitly t
 aken into account and the membrane behaviour is studied as a function of t
 he spontaneous curvature.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats (I23.
 EG.102)\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Elisa Floris: Statistical physics of molecular sorting in living ce
 lls
URL:https://talks-calendar.ista.ac.at/events/4171
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