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DTSTAMP:20260424T143334Z
UID:6267c1da514b1782798959@ist.ac.at
DTSTART:20230516T160000
DTEND:20230516T170000
DESCRIPTION:Speaker: Michaela Misova\nAbstract: Electrical synapses are oft
 en regarded as simple structures formed by channels called gap junctions. 
 Compared to the chemical synapse that has been extensively studied and cha
 racterized\, the molecular composition of electrical synapses is far less 
 understood. Much of what is known comes from heterologous studies of the g
 ap junction proteins on cell culture models while in vivo studies are spar
 se due to the complexity of the system\, technical limitations and investi
 gator bias. We aim to understand the in vivo biology of gap junctions usin
 g C. elegans as a model. To lay the groundwork for studying electrical syn
 apses\, we use a proximity labeling approach\, involving TurboID\, to char
 acterize the interactomes of two innexins that are expressed predominantly
  in neurons. We are setting up localization and functional assays to valid
 ate and further probe our findings. Our preliminary data identify scores o
 f proteins predicted to be enriched at electrical synapses and imply that 
 electrical synapses are sophisticated signalling nodes.
LOCATION:Central Bldg / O1 / Mondi 2(I01.O1.008)\, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Michaela Misova: Gap junction proteins and their molecular crew: In
 sights from C. elegans
URL:https://talks-calendar.ista.ac.at/events/4166
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