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DTSTAMP:20260424T143509Z
UID:6267c1da514b7395785658@ist.ac.at
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DESCRIPTION:Speaker: Wolfgang Baumeister\nhosted by Peter Jonas\nAbstract: 
 Cryo-electron tomography: The power of seeing the whole pictureTraditional
 ly\, structural biologists have approached cellular complexity in a reduct
 ionist manner by studying isolated and purified molecular components. This
  'divide and conquer' approach has been highly successful\, as evidenced b
 y the impressive number of entries in the PDB.However\, awareness has grow
 n in recent years that only rarely biological functions can be attributed 
 to individual macromolecules. Most cellular functions arise from their act
 ing in concert. Hence there is a need for methods developments enabling st
 udies performed in situ\, i.e. in unperturbed cellular environments. Sensu
  stricto the term 'structural biology in situ' should apply only to a scen
 ario in which the cellular environment is preserved in its entirety. Cryo 
 electron tomography (Cryo ET) has unique potential to study the supramolec
 ular architecture or 'molecular sociology' of cells. It combines the power
  of three-dimensional imaging with the best structural preservation that i
 s physically possible to achieve.We have used cryo-electron tomography to 
 study the 26S proteasome\, the main machinery for protein degradation\, in
  a number of cellular settings revealing its precise location\, assembly a
 nd activity status as well as its interactions with other molecular player
 s of the cellular protein quality control machinery. Another pathway for t
 he disposal of waste is autophagy. Cryo ET has allowed to visualize the bi
 ogenesis of autophagosomes in great detail.For realizing the full potentia
 l of cryo ET\, further advances in technology and methodology are needed.B
 aumeister W.: Cryo-electron tomography: A long journey to the inner space 
 of cells\, Cell\, 185(15):2649-2652 (2022)
LOCATION:Central Bldg / O1 / Mondi 2 (I01.O1.008)\, ISTA
ORGANIZER:eleftheria.krallibeller@ist.ac.at
SUMMARY:Wolfgang Baumeister: Cryo-electron tomography: The power of seeing 
 the whole picture
URL:https://talks-calendar.ista.ac.at/events/4161
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