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DTSTAMP:20260425T044211Z
UID:1683275400@ist.ac.at
DTSTART:20230505T103000
DTEND:20230505T113000
DESCRIPTION:Speaker: Kaïn van den Elsen\nhosted by Florian Schur\nAbstract
 : Positive-sense RNA viruses such as coronaviruses\, flaviviruses and alph
 aviruses pose a significant threat to public health due to their ability t
 o rapidly spread and cause widespread disease. Chikungunya virus (CHIKV) i
 s a mosquito-borne virus that causes a severe\, debilitating arthralgic di
 sease in humans\, leading to significant morbidity and causing chronic dis
 ease in a large proportion of patients which persists long after infection
 . Due to climate change\, the range of the CHIKV vectors is rapidly increa
 sing\, driving an accelerating incidence and emergence across the globe. C
 HIKV nonstructural protein 1 (NSP1) is known to induce the formation of ma
 ny protrusions in host cells\, allowing virions to spread to neighbouring 
 cells efficiently\, whilst avoiding immune surveillance. Despite extensive
  research into CHIKV\, a comprehensive understanding of the structural org
 anisation of proteins within the protrusions remains elusive. In this stud
 y\, we used state-of-the-art imaging techniques including in-situ cryo-e
 lectron tomography\, sub-tomogram averaging and super-resolution live-cell
 -imaging alongside cell signalling modulation to investigate the morpholog
 y and molecular basis of NSP1-induced protrusions. We present in-situ st
 ructures and organisation of NSP1\, actin and ribosomes\, the main compone
 nts of these protrusions\, and detail the complex interplay of the protein
 s involved in their formation. Our findings shed new light on the NSP1 ind
 uced mechanisms that govern viral cell-to-cell transmission and thus pave 
 the way for new therapeutic strategies aiming to combat viral infections.
LOCATION:Heinzel Seminar Room / OBW\, ISTA
ORGANIZER:omerhalil.unal@ist.ac.at
SUMMARY:Kaïn van den Elsen: Dissecting the molecular mechanism of chikungu
 nya virus cell-to-cell transmission
URL:https://talks-calendar.ista.ac.at/events/4131
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