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DTSTAMP:20260424T114323Z
UID:63bd47397c0c7297482236@ist.ac.at
DTSTART:20230511T110000
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DESCRIPTION:Speaker: Mirna Kramar\nhosted by Jérémie Palacci\nAbstract: C
 ells rely on signalling pathways to transduce signals from the environment
  to the inside of the cell\, generating behaviour and facilitating communi
 cation with their neighbours. The activity of signalling pathways — and 
 consequently communication— is normally modulated through ligand binding
 . The phenomenon of communication by electrical signals is a well-known ha
 llmark of neuronal function and has until recently been largely overlooked
  in non-neuronal cells. However\, the growing body of evidence demonstrate
 s that the electrical potential at the plasma membrane (Vmem) plays an imp
 ortant role in the function of the cell. There are intrinsic differences i
 n the Vmem between different cell types\, and its changes modulate the act
 ivity of the signalling pathways.In this talk\, we will delve into the mec
 hanisms of intra- and inter-cellular communication by means of electrical 
 signals\, in particular the potential differences between healthy and canc
 erous cells. Using pairs of isogenic cell lines\, optogenetic and chemical
  tools\, we measure\, manipulate and quantify the electrical potential at 
 the plasma membrane. Simultaneously\, we track the activity of ERK\, one o
 f the most important signalling pathways and a key player in the developme
 nt of cancer\, and quantify the impact of Vmem modulation on its activity.
  Finally\, we simulate the in-vivo setting by performing the measurements 
 on the co-culture of healthy and cancer cells\, and attempt to gain the fi
 rst insights on cell-to-cell communication through the coupling of electri
 cal signals and ERK activity in a mixed epithelium.
LOCATION:Big Seminar Room B (big) I23.EG /63 seats (I23.EG.102)\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Mirna Kramar: Cellular communication by means of electricity
URL:https://talks-calendar.ista.ac.at/events/4119
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