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DTSTART:20230326T030000
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BEGIN:VEVENT
DTSTAMP:20260424T135405Z
UID:6267c1da51491995439707@ist.ac.at
DTSTART:20230418T160000
DTEND:20230418T170000
DESCRIPTION:Speaker: Angus Silver\nhosted by Johann Danzl\nAbstract: Talk t
 itle: Decoding activity patterns across pyramidal cell dendritic trees dur
 ing spontaneous behavioursAbstract:Little is known about the extent of the
  information available to an individual neuron during behaviour. Decipheri
 ng the information conveyed by synaptic inputs impinging onto 3D dendritic
  trees requires recordings across many dendritic branches. To address this
  we used a non-linear acousto-optic lens 3D 2-photon microscope to selecti
 ve image the activity across the dendritic arbours of pyramidal cells in m
 otor cortex expressing GCaMP6f. To image a large fraction of the dendritic
  tree in vivo\, we combined high speed 3D imaging with our recently develo
 ped real-time 3D movement correction and semi-automated 3D dendritic traci
 ng. We carried out arboreal scans on cells expressing GCaMP6f in layer II/
 III motor cortex in head-fixed mice as they rested or ran on a treadmill a
 nd during air puffs. Our results indicate that pyramidal cells exhibit mos
 tly global\, multi-branch activation that is strongly coupled to the soma.
  Surprisingly\, modulation of branch activity was also evident. We used un
 supervised dimensionality reduction approaches to identify regions of the 
 dendritic tree that were comodulated and studied their relationship to beh
 avioural variables. Our results suggest dendritic regions are comodulated 
 and their activity correlates with behavioural variables.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:mmosiash@ist.ac.at
SUMMARY:Angus Silver: Decoding activity patterns across pyramidal cell dend
 ritic trees during spontaneous behaviours
URL:https://talks-calendar.ista.ac.at/events/4111
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