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DTSTAMP:20260424T143104Z
UID:1676991600@ist.ac.at
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DESCRIPTION:Speaker: Christopher Currin and Florian Schmidt\nAbstract: Spea
 ker: Christopher Currin (Postdoc\, Vogels group)Title: Human cortical 
 cultures and artificial models: Understanding individuals with epilepsyAb
 stractArtificial neural networks simplify complex biological circuits into
  tractable computational models to distil their essence and test our under
 standing. It is often said that the simplicity of artificial models underm
 ines their applicability to real brain dynamics. Typical efforts to addres
 s this mismatch add complexity to increasingly unwieldy models. We instead
  use simplified cortical cultures with two cortical neuron types derived f
 rom human induced pluripotent stem cells (hiPSCs) to compare model and rea
 lity. Our approach of deriving neural networks from hiPSCs also allows us
 \, for the first time\, to directly compare neural dynamics of epilepsy pa
 tients and close family “control” members. We uncovered surprisingly v
 ariable network activity across cultures from families with a common genet
 ic variant. We aim to explore this variability further by building data-dr
 iven models – “digital twins”\, or artificial reproductions of each 
 network – that allow rapid and reproducible probing of individuals’ dy
 namics. Furthermore\, the digital twins suggest ex vivo perturbation exper
 iments for further understanding of the individuals’ cultures and models
 .Our research showcases a promising personalised medicine approach for the
  understanding and treatment of people with epilepsy. It does so by using 
 data-driven modelling that starts to bridge an important theoretical-exper
 imental neuroscience gap for advancing our understanding of human neuron d
 ynamics.Speaker: Florian Schmidt (PhD. Jösch group)Title: Attentional
  Modulation of Neuronal Population Dynamics in the Superior ColliculusAbst
 ract :Attention can be defined as a set of neuronal mechanisms necessary f
 or adaptive and effective behavioural selection. This process also require
 s the ability to learn the value and meaning of a sensory event within a p
 articular context. Experimental evidence has implicated the superior colli
 culus\, a midbrain structure\, and areas of the prefrontal cortex in atten
 tion\, but the underlying neural mechanisms remain a black box. To study t
 he underlying mechanisms experimentally in mice\, I developed a modular be
 havioural training paradigm that involves (i) the learning of a reward-cou
 pled stimulus and (ii) allocation of attention to specific spatial locatio
 ns\, which is verified by behavioural performance metrics. These experimen
 ts are paired with 2-photon imaging providing direct and continuous monito
 ring of the neuronal activity of the superior colliculus with reliably hig
 h spatial resolution. In this talk\, I present the paradigm and my first r
 esults that indicate how reward association and trial performance are link
 ed with neuronal population dynamics.
LOCATION:Mondi 2\, ISTA
ORGANIZER:mariam.mosiashvili@ist.ac.at
SUMMARY:Christopher Currin and Florian Schmidt: NDT\, Christopher Currin an
 d Florian Schmidt
URL:https://talks-calendar.ista.ac.at/events/4021
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