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DTSTART:20170326T030000
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DTSTART:20171029T020000
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BEGIN:VEVENT
DTSTAMP:20260428T045833Z
UID:58d8c4af472a5842024424@ist.ac.at
DTSTART:20170410T110000
DTEND:20170410T120000
DESCRIPTION:Speaker: Diana Pinheiro\nhosted by Carl-Philipp Heisenberg\nAbs
 tract: During epithelial cytokinesis\, the remodelling of adhesive cell-ce
 ll contacts between the dividing cell and its neighbours has profound role
 s in the integrity\, arrangement and morphogenesis of proliferative tissue
 s. In both vertebrates and invertebrates\, this remodelling requires the a
 ctivity of non-muscle myosin II (MyoII) in the interphasic cells neighbour
 ing the dividing cell. However\, the mechanisms coordinating cytokinesis a
 nd MyoII activity in the neighbours are unknown. Here we find that in the 
 Drosophila notum epithelium\, each cell division is associated with a mech
 ano-sensing and transmission event controlling MyoII dynamics in the neigh
 bours. We established that the ring pulling forces promote local junction 
 elongation\, resulting in local E-cadherin (E-Cad) dilution at the ingress
 ing adherens junction (AJ). In turn\, the reduction of E-Cad concentration
  and the contractility of the neighbouring cells promote self-organized ac
 tomyosin flows\, ultimately leading to MyoII accumulation at the base of t
 he ingressing AJ. While force transduction has been extensively studied in
  the context of AJ reinforcement to stabilize adhesive cell-cell contacts\
 , we propose an alternative mechano-sensing mechanism able to coordinate a
 ctomyosin dynamics between epithelial cells and to sustain AJ remodelling 
 in response to mechanical forces.
LOCATION:Experimental Biology Room (I04.2OG - LAB)\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Diana Pinheiro: Transmission of cytokinesis forces via E-cadherin d
 ilution and actomyosin flows
URL:https://talks-calendar.ista.ac.at/events/398
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