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DTSTAMP:20260424T143219Z
UID:1679308200@ist.ac.at
DTSTART:20230320T113000
DTEND:20230320T123000
DESCRIPTION:Speaker: Carrie Bernecky\nhosted by Martin Loose\nAbstract: All
  cellular life depends on the regulated expression of genetic information.
  This information is stored in genomic DNA\, which must be transcribed int
 o RNA before it can be used. RNA is thus an important focal point for gene
  expression regulation\, and can even have regulatory activity itself. How
 ever\, how RNA is made and how it regulates gene expression is still incom
 pletely understood. Many RNA-containing complexes are flexible\, modular\,
  and lowly abundant\, making them challenging targets for study. Our group
  combines cryo-electron microscopy and biochemical techniques to elucidate
  the mechanisms of action of RNA regulatory complexes.In my seminar\, I wi
 ll present two examples of RNA-based regulation. First\, I will describe h
 ow a human noncoding RNA can directly inhibit gene expression. After cellu
 lar stress\, this RNA becomes highly abundant and can help shut down new R
 NA production. Second\, I will describe how the recognition of RNA structu
 re stimulates human immune signaling pathways. These pathways are importan
 t for defense against pathogens\, as well as contributors to autoimmune di
 sease. Altogether\, through our studies we gain an understanding of how RN
 A-protein complexes assemble and regulate cellular RNA metabolism.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Carrie Bernecky: How does RNA regulate gene expression?
URL:https://talks-calendar.ista.ac.at/events/3969
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