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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T110607Z
UID:58cba8d3ab13e936497077@ist.ac.at
DTSTART:20170411T133000
DTEND:20170411T143000
DESCRIPTION:Speaker: Christoph Rademacher\nhosted by Gasper Tkacik\nAbstrac
 t: The surface of every living cell is covered with a dense matrix of glyc
 ans. Its particular composition and structure codes important messages in 
 cell-cell communication\, influencing development\, differentiation\, and 
 immunological processes. The matrix is formed by highly complex biopolymer
 s whose compositions vary from cell to cell\, even between genetically ide
 ntical cells. The function of this glycocalyx is mediated by a multivalent
  display of glycans that interact with lectins\, glycan-binding proteins e
 xpressed by all living organisms. \nIn this talk\, I will give an introduc
 tion into basic glycobiology and the guiding principles we can derive to f
 oster our molecular design strategies for targeted immunotherapy. In parti
 cular\, I will focus on our ongoing research into the specific delivery of
  nanoparticles to Langerhans cells\, a dendritic cell subset of the human 
 skin\, for therapeutic tumor vaccination. For this\, we apply highly sensi
 tive biophysical techniques such as NMR and SPR combined with cell-based a
 ssays inspired by the lessons glycobiology has taught us on how specific i
 nteractions can arise from  multivalent display of sugars.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Christoph Rademacher: From basic glycobiology to targeted immunothe
 rapy
URL:https://talks-calendar.ista.ac.at/events/392
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