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DTSTAMP:20260425T051634Z
UID:1698053400@ist.ac.at
DTSTART:20231023T113000
DTEND:20231023T123000
DESCRIPTION:Speaker: Gijsje Koenderink\nhosted by Andela Saric\nAbstract: C
 ells and tissues are dynamic but also need to withstand large mechanical l
 oads. This paradoxical mechanical behavior is governed by fibrous protein 
 scaffolds known as the cytoskeleton and the extracellular matrix. It is st
 ill poorly understood how these biopolymer networks can combine mechanical
  strength with the ability to dynamically adapt their structure and mechan
 ics. I will summarize our recent findings obtained via quantitative measur
 ements on synthetic cells reconstituted from purified biological constitue
 nts. I will focus on the role of mechanical crosstalk between the four cyt
 oskeletal networks in the cell: actin filaments\, microtubules\, intermedi
 ate filaments and septins. These four filamentous systems contribute diffe
 rent structural and dynamical properties\, enabling specific cellular func
 tions. I will highlight our recent efforts to biochemically reconstitute t
 heir interplay\, which allows us to connect the collective mechanical pro
 perties of cytoskeletal networks to the underlying molecular interactions\
 , which involve cytoskeletal crosslinkers\, motors\, and the plasma membra
 ne. Our findings may eventually be interesting to guide the search for sel
 ective anticancer drugs\, since cancer cells often overexpress specific se
 ptins\, intermediate filaments\, and cytoskeletal crosslinker proteins lea
 ding to abnormal mechanical behaviors.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Gijsje Koenderink: The cell as a material
URL:https://talks-calendar.ista.ac.at/events/3915
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