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DTSTART:20170326T030000
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DTSTART:20171029T020000
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BEGIN:VEVENT
DTSTAMP:20260428T233017Z
UID:58c940d42d9f2834052992@ist.ac.at
DTSTART:20170328T100000
DTEND:20170328T110000
DESCRIPTION:Speaker: Martin Lackinger\nhosted by Ryuichi Shigemoto\nAbstrac
 t: The brain-enriched miR-134 was one of the first miRNAs for which a func
 tion at the synapse and activity dependent dendritogenesis has been descri
 bed in detail. Its gene is found within a cluster of miRNA in the Gtl2/Dlk
 1 domain that is also described as the miR379-410 cluster that is the larg
 est known placenta mammal specific miRNA cluster. In this cluster\, 39 miR
 NA genes are expressed only from the maternal allele and are mainly expres
 sed in the brain. Currently\, less is known about the molecular and behavi
 oral function of the miR379-410 locus and their regulative miRNAs in vivo 
 during different postnatal development stages. Using a miR379-410 knockout
  mouse model\, we performed a large battery of behavioral tests and molecu
 lar/cellular applications to gain insight into the physiological mechanism
 . We mainly found that the absent of the miR379-410 expression is associat
 ed with a hypersocial phenotype\, demonstrated in social interaction appro
 aches and increased emitted ultrasonic vocalization calls. This indicates\
 , that miRNAs of this cluster could play a relevant role in neural circuit
 s of emotion regulation. At the molecular level\, the hypersocial phenotyp
 e of the knockout mice were further assisted by changes in hippocampal gen
 e expression levels\, as shown by total RNA deep sequencing on which targe
 t validation is now still under investigation.
LOCATION:Meeting room 2nd floor / Lab Bldg East (I06.02.403)\, ISTA
ORGANIZER:ddomniso@ist.ac.at
SUMMARY:Martin Lackinger: Behavioral and molecular characterization of the 
 miR379-410 knockout mouse
URL:https://talks-calendar.ista.ac.at/events/387
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