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DTSTAMP:20260425T051724Z
UID:62cbd2e00581d964244664@ist.ac.at
DTSTART:20220720T110000
DTEND:20220720T120000
DESCRIPTION:Speaker: Diana Serbanescu\nhosted by Andela Saric\, Martin Loos
 e\nAbstract: Cell size control emerges from a regulated balance between th
 e rates of cell growth and division. In bacteria\, simple quantitative law
 s connect cellular growth rate to ribosome abundance. However\, it remains
  poorly understood how translation regulates bacterial cell size and shape
  under growth perturbations. We developed a whole-cell model for growth dy
 namics of rod-shaped bacteria that links ribosomal abundance with cell geo
 metry\, division control\, and the extracellular environment. Our work rev
 eals that cell size maintenance under nutrient perturbations requires a ba
 lanced trade-off between ribosomes and division protein synthesis. Deviati
 ons from this trade-off relationship are predicted under translation inhib
 ition\, leading to distinct modes of cell morphological changes\, in agree
 ment with single-cell experimental data on Escherichia coli. Using a whole
 -cell model for the regulation of cell shape and growth by antibiotics\, w
 e predict shape transformations that bacteria can utilize to increase thei
 r fitness in the presence of antibiotics.
LOCATION:Heinzel Seminar Room / Office Bldg West (I21.EG.101)\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Diana Serbanescu: Quantitative modelling of bacterial growth physio
 logy\, cell size and shape control
URL:https://talks-calendar.ista.ac.at/events/3869
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