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DTSTAMP:20260424T062921Z
UID:1663579800@ist.ac.at
DTSTART:20220919T113000
DTEND:20220919T123000
DESCRIPTION:Speaker: Kristen M. Harris\nhosted by Peter Jonas\nAbstract: Th
 e postsynaptic density comprises regions associated with presynaptic docke
 d vesicles in the active zones (AZ)\, and nascent zones (NZ) without presy
 naptic vesicles. Induction of LTP recruits presynaptic vesicles to the NZs
 \, converting them to AZs thereby stabilizing new nanocolumns between vesi
 cles and postsynaptic receptors. Later\, new NZs are built allowing augmen
 tation of LTP as a mechanism for the advantage of spaced over massed learn
 ing.Relevant publications:Jung JH\, Kirk LM\, Bourne JN\, Harris KM (2021)
  Shortened tethering filaments stabilize presynaptic vesicles in support o
 f elevated release probability during LTP in rat hippocampus. PNAS\, 118 (
 17):e2018653118. (PDF (https://synapseweb.clm.utexas.edu/sites/default/fil
 es/synapseweb/files/2021_pnas_jung_harris_shortened_tethering_filaments.pd
 f?m=1619811567))Chirillo MA\, Waters MS\, Lindsey LF\, Bourne JN\, Harris 
 KM (2019) Local resources of polyribosomes and SER promote synapse enlarg
 ement and spine clustering after long-term potentiation in adult rat hippo
 campus. Scientific Reports\, 9(1):3861. PMCID: PMC6405867. (PDF (https://s
 ynapseweb.clm.utexas.edu/sites/default/files/synapseweb/files/2019_sci_rep
 _chirillo_harris_local_resources_of_polyribosomes_and_ser.pdf?m=1552499986
 ))Bell ME\, Bourne JN\, Chirillo MA\, Mendenhall JM\, Kuwajima M\, Harris
  KM (2014) Dynamics of nascent and active zone ultrastructure as synapses 
 enlarge during long-term potentiation in mature hippocampus. J Comp Neurol
 \, 522(17):3861-84. PMCID: PMC4167938. (2MB PDF (https://synapseweb.clm.ut
 exas.edu/sites/default/files/synapseweb/files/2014_jcompneurol_bellharris_
 dynamicsofnascentzones.pdf))
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Kristen M. Harris: Structural synaptic plasticity as a basis for sp
 aced learning
URL:https://talks-calendar.ista.ac.at/events/3789
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