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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T045818Z
UID:58bd3729851ca884244046@ist.ac.at
DTSTART:20170405T094500
DTEND:20170405T104500
DESCRIPTION:Speaker: Edouard Hannezo\nAbstract: Branching morphogenesis has
  been a subject of abiding interest. \nAlthough much is known about the un
 derlying signaling pathways\, it remains unclear how the macroscopic featu
 res of branched organs\, including their size\, network topology and spati
 al patterning\, are encoded. Here we show that\, in mouse mammary gland\, 
 kidney and human prostate\, these features can be explained quantitatively
  within a single unifying framework of branching and annihilating random w
 alks. Based on large-scale organ reconstructions and proliferation kinetic
 s\, we propose that morphogenesis follows from the proliferative activity 
 of equipotent ductal tips that stochastically branch and randomly explore 
 their environment\, but compete neutrally for space\, becoming proliferati
 vely inactive when in proximity with neighboring ducts. These results show
  that complex branched epithelial structures in mammalian tissues develop 
 as a self-organized process\, reliant upon a strikingly simple\, but gener
 ic\, set of local rules\, without recourse to a rigid and deterministic se
 quence of genetically programmed events.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:bkunes@ist.ac.at
SUMMARY:Edouard Hannezo: Self-organizing principles in epithelial morphogen
 esis
URL:https://talks-calendar.ista.ac.at/events/375
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