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DTSTART:20220327T030000
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DTSTAMP:20260404T110148Z
UID:625e78e03f798183580120@ist.ac.at
DTSTART:20220420T123000
DTEND:20220420T133000
DESCRIPTION:Speaker: Jolie Carlisle\nhosted by Nick Barton\nAbstract: Repro
 ductive proteins mediating fertilization commonly exhibit rapid sequence d
 iversification driven by positive selection. This pattern has been observe
 d among nearly all taxonomic groups\, including mammals\, invertebrates\, 
 and plants\, and is remarkable given the essential nature of the molecular
  interactions mediating fertilization. I will discuss my research investig
 ating how sequence divergence\, duplication\, and gene loss events can tog
 ether generate remarkable diversity in fertilization genes between species
 . My research largely centers on the sperm and egg proteins lysin and VERL
 \, a pair of egg gamete recognition genes mediating vitelline envelope (VE
 ) dissolution in the marine gastropod mollusk abalone (genus Haliotis). Us
 ing quantitative biophysical methods\, we biochemically characterized the 
 species-specific mechanisms of VE dissolution in abalone and using experim
 entally guided molecular docking provide evidence that mechanisms mediatin
 g VE dissolution in abalone are likely similar to mechanisms of egg coat d
 issolution in mammals.
LOCATION:Online Event ()\, ISTA
ORGANIZER:apal@ist.ac.at
SUMMARY:Jolie Carlisle: Molecular Mechanisms and Evolution of Fertilization
  Proteins
URL:https://talks-calendar.ista.ac.at/events/3713
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