BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20170326T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20171029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260428T112224Z
UID:58c6a9667a5b1976628386@ist.ac.at
DTSTART:20170411T110000
DTEND:20170411T120000
DESCRIPTION:Speaker: Jorge Alegre-Cebollada\nAbstract: The heart is a mecha
 nical machine that has little room for failure. Differently to pumps manuf
 actured by men\, the heart is built upon soft tissue. What are the mechani
 cal properties of cardiac tissue and its constituent proteins sustaining t
 he remarkable activity of the heart? How is the elasticity of the myocardi
 um tuned to accommodate the expansion of the ventricles during diastole? H
 ow do mutations in proteins with a mechanical role trigger the development
  of life-threatening cardiomyopathies? Since the mechanical properties of 
 proteins are not accessible to standard bulk biochemical techniques\, our 
 lab takes a multidisciplinary approach to try to answer all these question
 s. We specialize in single molecule methods using atomic force microscopy 
 (AFM)\, which are able to measure the effects of mechanical forces on prot
 eins. We focus on titin and cardiac myosin binding protein C\, two key pro
 teins that enable and modulate contractility of the sarcomere by establish
 ing elastic tethers.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:amally@ist.ac.at
SUMMARY:Jorge Alegre-Cebollada: Tales from spring brakes
URL:https://talks-calendar.ista.ac.at/events/370
END:VEVENT
END:VCALENDAR