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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260428T111131Z
UID:58c2c0a90ffef572874227@ist.ac.at
DTSTART:20170315T120000
DTEND:20170315T130000
DESCRIPTION:Speaker: Kaila Kai\nhosted by Gaia Novarino\nAbstract: Electric
 al activity in neurons requires a seamless functional coupling between pla
 smalemmal ion channels and ion transporters. While ion channels have been 
 studied intensively for several decades\, work on ion transporters is attr
 acting a steeply rising number of researchers into this field. This is bec
 ause in recent years\, it has become evident that a family of ion transpor
 ters\, the cation-chloride cotransporters (CCCs)\, in particular the K–Cl
 ? cotransporter 2 (KCC2) and the Na-K-2Cl cotransporter 1 (NKCC1)\, have b
 een shown to have seminal roles in shaping neuronal development as well as
  synaptic signalling and connectivity. Studying the functions of these tra
 nsporters may lead to major paradigm shifts in our understanding of the me
 chanisms underlying brain development and plasticity in health and disease
 . CCCs are also promising candidates as CNS drug targets for treatment of 
 a large variety of brain dysfunctions and diseases\, ranging from autism s
 pectrum disorders to epilepsy and stroke.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:ddomniso@ist.ac.at
SUMMARY:Kaila Kai: Chloride transporters KCC2 and NKCC1 in neuronal develop
 ment\, signalling and plastici
URL:https://talks-calendar.ista.ac.at/events/368
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