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TZID:Europe/Vienna
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DTSTART:20170326T030000
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DTSTART:20161030T020000
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BEGIN:VEVENT
DTSTAMP:20260428T072820Z
UID:58bedf67c11ab313919841@ist.ac.at
DTSTART:20170315T110000
DTEND:20170315T120000
DESCRIPTION:Speaker: Sabrina Ladstätter\nhosted by Johann Georg Danzl\nAbs
 tract: Sexual reproduction culminates in formation of a totipotent zygote 
 with the potential to produce a whole organism. Sperm chromatin reorganiza
 tion and epigenetic reprogramming involving changes in DNA and histone mod
 ifications generate a totipotent mouse embryo within one cell cycle. Activ
 e DNA demethylation of the paternal genome has been proposed to involve ba
 se excision and DNA repair-based mechanisms. The nature and consequence of
  DNA lesions generated during reprogramming is not known. Using mouse gene
 tics and chemical biology\, we discovered that Tet3-dependent zygotic repr
 ogramming generates paternal DNA lesions that are monitored by a surveilla
 nce mechanism. In vivo structure-function rescue assays revealed that cohe
 sin-dependent repair of paternal DNA lesions prevents activation of a Chk1
 -dependent checkpoint that delays mitotic entry. We propose the zygotic ch
 eckpoint senses DNA lesions generated during paternal DNA demethylation an
 d ensures reprogrammed loci are repaired before mitosis to prevent chromos
 ome fragmentation\, embryo loss and infertility.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Sabrina Ladstätter: A checkpoint ensures repair of DNA lesions dur
 ing zygotic reprogramming
URL:https://talks-calendar.ista.ac.at/events/362
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