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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T111142Z
UID:58b0256444338493233052@ist.ac.at
DTSTART:20170403T101500
DTEND:20170403T111500
DESCRIPTION:Speaker: Attila Losonczy\nAbstract: Learning and remembering wh
 ere and when salient events occur in space and time are essential for adap
 tive behaviors. Both spatial navigation and episodic memory have been link
 ed to the mammalian hippocampus\, but the detailed mechanisms at cellular 
 and circuit levels remain poorly understood. To address these questions\, 
 we use in vivo functional imaging to monitor the activity of identified ex
 citatory\, inhibitory and neuromodulatory circuit motifs in the hippocampu
 s of behaving mice during spatial exploration\, fear learning and goal-dir
 ected learning. The talk will focus on our recent efforts aimed at dissect
 ing functional roles of multimodal microcircuits at the dentate gyrus inpu
 t and at the CA1 output nodes of the hippocampus. I will summarize how var
 ious types of dentate gyrus principal neurons – adult-born and mature gra
 nule cells\, and hilar mossy cells contribute to context encoding and disc
 rimination. We also monitored activity in deep and superficial subpopulati
 ons of CA1 pyramidal cells\, and assessed the relationship between sublaye
 r dynamics and learning.  Finally\, I will present findings on how goal-or
 iented learning is supported by disinhibitory GABAergic circuits in CA1. T
 ogether\, our results demonstrate a functional division of labor among sub
 populations of principal neurons during hippocampal-dependent behaviors.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Attila Losonczy: Dissecting hippocampal circuits operations for nav
 igation and learning
URL:https://talks-calendar.ista.ac.at/events/361
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