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DTSTAMP:20260406T043405Z
UID:1652454000@ist.ac.at
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DESCRIPTION:Speaker: Venki Ramakrishnan\nhosted by Leonid Sazanov\nAbstract
 : The initiation of translation is a key regulatory step in protein synthe
 sis. Defects in initiation are related to diseases including cancer\, and 
 many viruses hijack the protein synthesis machinery by shutting down initi
 ation of host genes and using alternative intiation mechanisms. I will des
 cribe how the cryoelectron microscopy can be used to capture ribosomal com
 plexes in various states of initiation and thus shed light on the mechanis
 m of initiation.BioVenki Ramakrishnan received his bachelor’s degree in 
 physics from Baroda University in India in 1971 and his Ph.D. in physics f
 rom Ohio University in 1976. He then studied biology for two years at the 
 University of California\, San Diego before beginning his postdoctoral wor
 k with Peter Moore at Yale University. Since 1999\, he has been a group le
 ader at the MRC Laboratory of Molecular Biology in Cambridge\, England. He
  received the Nobel Prize for Chemistry in 2009 and was the president of t
 he Royal Society from 2015-2020.In 2000\, his laboratory determined the at
 omic structure of the 30S ribosomal subunit and its complexes with ligands
  and antibiotics. This work led to insights into how the ribosome “reads
 ” the genetic code\, as well as antibiotic function. Ramakrishnan’s la
 b subsequently determined high-resolution structures of functional complex
 es of the entire ribosome at various stages along the translational pathwa
 y\, which led to insights into its role in protein synthesis during decodi
 ng\, peptidyl transfer\, translocation and termination. More recently his 
 laboratory has been applying cryoelectron microscopy to study eukaryotic a
 nd mitochondrial translation.Ramakrishnan is the author of Gene Machine\, 
 a very frank popular memoir about the race for the structure of the riboso
 me.ISTA Lecture Young LoungeAhead of the lecture\, our Young Lounge format
  offers high school students and their teachers the possibility to interac
 t with the speaker in a less formal setting. For details and registration 
 please go to the ISTA Lecture Young Lounge page (https://ista.ac.at/de/new
 s-events/event/?eid=3704).Registration for the LecturePlease register for 
 the ISTA Lecture using the below button.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Venki Ramakrishnan: Initiation of translation in eukaryotes and bac
 teria
URL:https://talks-calendar.ista.ac.at/events/3588
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