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DTSTART:20220327T030000
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DTSTAMP:20260404T052320Z
UID:612f3252ab300562481122@ist.ac.at
DTSTART:20220309T121500
DTEND:20220309T140000
DESCRIPTION:Speaker: Tom Ellis\nhosted by Nick Barton\nAbstract: Plant viru
 ses account for enormous agricultural losses worldwide\, and the most robu
 st way to combat this is to identify genetic material conferring resistanc
 e to those pathogens.  Here\, we screen a large panel of Arabidopsis thali
 ana natural inbred lines for four disease-related traits in response to in
 fection by nave and evolved strains of the natural pathogen turnip mosaic 
 virus (TuMV). Using GWAS\, we detected a strong\, replicable association b
 etween a 50kb region on chromosome 2 and a 10-fold increase in relative ri
 sk of necrosis in response to infection. The region contains several plaus
 ible causal genes\, as well as abundant structural variation that could be
  either a driver or a consequence of the disease resistance locus. Suscept
 ible alleles are found worldwide\, and their distribution is consistent wi
 th a trade-off between resistance during viral outbreaks and a cost of res
 istance otherwise\, leading to negative frequency-dependent selection.
LOCATION:I22 Lakeside View (I22.O1.006)\, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Tom Ellis: The genetic basis of turnip-mosaic-virus resistance in A
 rabidopsis thaliana
URL:https://talks-calendar.ista.ac.at/events/3577
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