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DTSTART:20170326T030000
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DTSTAMP:20260428T112237Z
UID:58b005568ab75702024942@ist.ac.at
DTSTART:20170421T150000
DTEND:20170421T170000
DESCRIPTION:Speaker: Raimund Dutzler\nhosted by Gaia Novarino -in cooperati
 on with the FWF-Doctoral Program\nAbstract: The TMEM16 proteins constitute
  a family of membrane proteins with an unusual functional breadth\, which 
 includes lipid scramblases and Cl- channels. Both functional branches are 
 activated by calcium\, acting from the intracellular side\, and they share
  a common architecture\, which was defined by the structure of the lipid s
 cramblase nhTMEM16 (1). In this protein\, each subunit of the homo-dimeric
  protein encompasses ten transmembrane helices and structured cytosolic do
 mains. The structural features of subunits suggest that the dimeric protei
 n harbors two locations for catalysis that are independent with respect to
  activation and lipid conduction. In scramblases\, the ‘subunit cavity’\
 , a hydrophilic membrane-traversing furrow contained within each subunit t
 hat is exposed to the lipid bilayer provides a path for polar lipid headgr
 oups across the membrane. It contains a conserved Ca2+-binding site locate
 d within the hydrophobic core of the membrane\, which regulates activation
  in both channels and scramblases. As shown by electrophysiology the ion c
 hannel TMEM16A contains two ion conduction pores that are independently ac
 tivated by Ca2+ (2). The nhTMEM16 structure thus provides insight into fun
 ctional mechanisms underlying lipid movement in scramblases and ion conduc
 tion in channels of the TMEM16 family. 1. J. D. Brunner\, N. K. Lim\, S. S
 chenck\, A. Duerst\, R. Dutzler\, X-ray structure of a calcium-activated T
 MEM16 lipid scramblase. Nature 516\, 207-212 (2014). 2. N. K. Lim\, A. K. 
 Lam\, R. Dutzler\, Independent activation of ion conduction pores in the d
 ouble-barreled calcium-activated chloride channel TMEM16A. J Gen Physiol 1
 48\, 375-392 (2016).\n
LOCATION:Seminar room Big Ground floor / Office Bldg West (I21.EG.101)\, IS
 TA
ORGANIZER:ddomniso@ist.ac.at
SUMMARY:Raimund Dutzler: Mechanistic relationships in the TMEM16 family of 
 calcium activated chloride channels
URL:https://talks-calendar.ista.ac.at/events/352
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