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DTSTAMP:20260424T143329Z
UID:1663925400@ist.ac.at
DTSTART:20220923T113000
DTEND:20220923T123000
DESCRIPTION:Speaker: Gina Turrigiano\nhosted by Maximilian A. Jösch\nAbstr
 act: Our brains must generate and maintain stable activity patterns over d
 ecades of life\, despite the dramatic changes in circuit connectivity and 
 function induced by learning and experience-dependent plasticity. How do o
 ur brains balance the opposing need for plasticity and stability? Over the
  past two decades we and others have discovered a family of “homeostatic
 ” negative feedback mechanisms that are theorized to stabilize overall b
 rain activity while allowing specific connections to be reconfigured by ex
 perience. Here I discuss recent work demonstrating that individual neocort
 ical neurons in freely behaving animals indeed have a homeostatic activity
  set-point\, to which they return in the face of perturbations. Intriguing
 ly\, this firing rate homeostasis is gated by sleep/wake states in a manne
 r that depends on the direction of homeostatic regulation\, and is comprom
 ised in an animal model of autism spectrum disorder. Finally\, I’ll disc
 uss some unpublished work exploring the possibility that these activity se
 t points are flexible during learning. Together our findings suggest that 
 loss of homeostatic plasticity in some neurological disorders may render c
 entral circuits unable to compensate for the normal perturbations induced 
 by development and learning.
LOCATION:Mondi 2 (Special location)\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Gina Turrigiano: The ups and downs of firing rate homeostasis
URL:https://talks-calendar.ista.ac.at/events/3458
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