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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260428T224328Z
UID:58a2ae13d0b9b574456499@ist.ac.at
DTSTART:20170322T094500
DTEND:20170322T104500
DESCRIPTION:Speaker: Jonathan Elegheert\nAbstract: The human brain consists
  of billions of neuronal cells assembled into networks that support cognit
 ive functions such as learning and memory formation. Dedicated cellular ju
 nctions\, termed synapses\, form the basic units of communication between 
 these neurons.\nAt synaptic sites\, neurotransmitter receptors are integra
 ted into synapse-spanning protein complexes\; these large assemblies suppo
 rt fundamental processes such as synapse formation\, expression of synapti
 c plasticity\, and receptor signaling.\nIn this talk\, I will focus on the
  three-dimensional structure determination of the prototypical complex for
 med between pre-synaptic neurexin (NRX)\, the soluble synapse organizer ce
 rebellin (Cbln) and the post-synaptic ionotropic glutamate receptor (iGluR
 ) Delta-2 (GluD2). I will discuss how this complex determines both synapse
  formation and agonist-dependent metabotropic GluD2 signaling in the cereb
 ellum.\nThis work provides the first structural snapshots of a synaptic or
 ganizer protein captured in an encounter complex with its neurotransmitter
  receptor\, and underscores that synergy between protein and small molecul
 e ligands for receptor activation constitutes a principle that is likely r
 ecapitulated throughout the brain.\n\nReference: Structural basis for inte
 gration of GluD receptors within synaptic organizer complexes. Elegheert J
  et al. Science. 2016 Jul 15\;353(6296):295-9
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:bkunes@ist.ac.at
SUMMARY:Jonathan Elegheert: Mind the gap: Structural snapshots of synaptic 
 organizing proteins in action
URL:https://talks-calendar.ista.ac.at/events/342
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