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DTSTAMP:20260404T082227Z
UID:61896fdac0edc596266719@ist.ac.at
DTSTART:20211123T133000
DTEND:20211123T143000
DESCRIPTION:Speaker: Pico Caroni\nhosted by Peiping Lin (Jonas Group)\nAbst
 ract: Autism Spectrum Disorder (ASD) is a mental condition involving genet
 ic and environmental components. The underlying circuit mechanisms are unc
 lear\, but behaviorally\, aversion towards unfamiliarity\, a hallmark of a
 utism\, might be involved. Understanding and treating autism would likely 
 benefit from mechanistic studies in model organisms\, but whether bona fid
 e ASD-like deficits can be modeled and investigated in mice has remained u
 nclear. I will discuss recent results from our lab providing evidence that
  in Shank3-/- ASD model mice\, exposure to novel environments produces lon
 g-lasting failure to engage and repetitive behaviors upon re-exposure\, tw
 o hallmarks of autism. In Shank3-/- mice\, a prelimbic cortex (PreL)-depen
 dent memory upon first exposure led to failure to recruit appropriate PreL
 ->Tail of striatum activity required for engagement at re-exposure. Inclus
 ion of familiar features at first exposure prevented subsequent failure to
  engage in Shank3-/- mice. Therefore\, novel context experience has a key 
 role to trigger ASD-like phenotypes in genetically predisposed mice\, and 
 behavioral therapies involving familiarity and enrichment might prevent th
 e emergence of ASD phenotypes.
LOCATION:Online Event (https://istaustria.zoom.us/j/93863516836?pwd=c2pDVXJ
 vcTh1V0NFVm4zamdjcE1iQT09  Meeting ID: 938 6351 6836  Passcode: 538453)\, 
 ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Pico Caroni: A behavioral and network mechanism accounting for hall
 marks of autism in mice
URL:https://talks-calendar.ista.ac.at/events/3416
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